![]() ![]() 1,2 In addition, repopulation of the heart by inducing myocytic proliferation has been proposed to be a realistic future option for cardiac repair. Many congenital malformations result from impaired cardiac growth. Growth of the heart is tightly regulated such that the distinct components achieve their appropriate proportions and are appropriately interconnected. Second, they demonstrate that regional increase in size of myocytes contributes significantly to chamber formation. First, they support a model of early cardiac morphogenesis in 2 stages. The significance of these observations is 2-fold. The largest cells were found at the ventral side of the heart tube, which corresponds to the site of the forming ventricle, as well as the site where proliferation is reinitiated. The proliferation of these small precursor cells ceases as they differentiate into overt cardiomyocytes, producing a slowly proliferating straight heart tube composed of cells increasing in size. These reconstructions reveal that the early heart tube is recruited from a pool of rapidly proliferating cardiac precursor cells. We have made quantitative reconstructions of embryonic chicken hearts ranging in stage from the fusion of the heart-forming fields to early formation of the chambers. Increase in cell size and proliferation of myocytes are key processes in cardiac morphogenesis, yet their regionalization during development of the heart has been described only anecdotally. Customer Service and Ordering Information. ![]() ![]() Stroke: Vascular and Interventional Neurology.Journal of the American Heart Association (JAHA).Circ: Cardiovascular Quality & Outcomes.Arteriosclerosis, Thrombosis, and Vascular Biology (ATVB). ![]()
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